The Malbim points out how this verse shows how selfless Esther was. According to him, what Esther was saying was that, if she is punished for approaching the king, at least only she will die – and the rest of the Jews will remain.
The Talmud (Megillah 15a) writes that Esther’s repeating “I will be destroyed” means that, just as she lost her father by being orphaned, so is she expecting to lose to her relationship to Mordechai through this act.
R’ Henach Leibowitz explains the Talmud’s use of the phrase “my father’s house” that one of our duties in life is to utilize our past experiences to further our personal growth. He continues that an orphan, like Esther, should use the loss of their parents to reawaken the feeling of trust in H-Shem that orphan had when still with parents.
R’ Moshe Dovid Valle writes that Esther used this phrase to indicate that she knew she would be disappointing one king or another – either Achashverosh or the King of kings. Either way, she was concerned she would be losing one king.
R’ Shimon Schwab wonders why Esther is concerned about losing her husband if she is anyway using a sheid to get out of relations with Achashverosh. He explains that the demon was created miraculously in reward for her resisting the gentile king. Such a miracle would not occur once she submits to him.
R’ David Forman writes in The Queen You Thought You Knew that there is a parallel verse in the Torah where the word ka’asher is followed by a double-verb. When Yaakov allows his sons to bring Binyamin to Mitzrayim he says, “ka’asher shakolti, shakolti” (“as I am mourning, so I am mourning”) (Bireishis 33:14). The parallel phrasing also parallels similar situations of national strife; Just as there, friction between Jews caused the threat on Jewish existence, and peace between Jews would bring their redemption.
Class participant RS pointed out another parallel in the fact that Esther descends from King Shaul, who was from the tribe of Binyamin.